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Method Of Action
Depression and therefore SSRI action is not fully understood. There are a variety of theories on the neurophysiology of depression but one is that there's a lack of stimulation of neurons at the synapse. Serotonin is a neurotransmitter and SSRIs inhibit serotonin reuptake in the synaptic cleft, increasing stimulation of the post-synaptic neuron.
- Anxiety - in the first 2 weeks, anxiety will increase with SSRI alone. So diazepam must be prescribed alongside
- Some personality disorders
- Premature ejaculation
The most important of these with regards to psychiatry are depression and, to lesser extent though still important anxiety. SSRIs are the first-line pharmocological treatment in both these conditions.
- Hepatic impairment
There is a large number of potential side-effects of SSRIs. However the main two are:
- GI upset
- Sexual dysfunction (including loss of libido)